Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fever and fever syndrome--current problems.

M Iriki1

  • 1Department of Physiology, Yamanashi Medical College, Japan.

The Japanese Journal of Physiology
|January 1, 1988
PubMed
Summary

Fever research now focuses on how its thermal and non-thermal aspects defend the host against infection. Key discoveries link interleukin 1 to the acute phase response and immune activation during fevers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of halothane and enflurane on the peripheral vasoconstriction and shivering induced by internal body cooling in rabbits.

Journal of anesthesia·2013
Same author

The difference between Japan and other countries, in particular the United Kingdom, in views regarding the teaching of geriatrics to undergraduate medical students.

Medical education·1999
Same author

Regional differentiation of sympathetic efferents during fever.

Progress in brain research·1998
Same author

Brain angiotensin II tonically modulates sympathetic baroreflex in rabbit ventrolateral medulla.

The American journal of physiology·1996
Same author

[University education in geriatrics--present status and future prospects of gerontology and geriatrics education in pathology].

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·1996
Same author

[Undergraduate teaching of geriatric medicine in western countries--literature review].

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·1996

Area of Science:

  • Neuroscience
  • Immunology
  • Physiology

Background:

  • Fever research has evolved from studying temperature regulation to understanding the broader fever syndrome.
  • Interleukin 1 has been identified as a key endogenous pyrogen involved in the acute phase reaction.
  • Fever is increasingly viewed as a host-defense mechanism against microbial infections.

Purpose of the Study:

  • To review the current understanding of pyrogen-induced fever.
  • To examine the roles of humoral factors and neurophysiological events in fever.
  • To elucidate the contributions of thermal and non-thermal fever components to host defense.

Main Methods:

  • Review of existing research on fever pathophysiology.
  • Analysis of the role of endogenous pyrogens, particularly interleukin 1.
  • Investigation into the significance of prostaglandin (PG) synthesis in fever generation.

Main Results:

  • Elucidation of interleukin 1 as a central mediator in fever and acute phase responses.
  • Recognition of fever as a complex syndrome with both thermal and non-thermal defense functions.
  • Understanding the involvement of prostaglandins (PGs) as central mediators in fever.

Conclusions:

  • Fever is a crucial host-defense mechanism involving complex humoral and neurophysiological pathways.
  • Interleukin 1 plays a significant role in mediating fever and immune responses.
  • Antipyretic drugs function by inhibiting prostaglandin synthesis, a key component of fever generation.

Related Experiment Videos