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Functional Evolution of Subolesin/Akirin
Sara Artigas-Jerónimo1, Margarita Villar1, Alejandro Cabezas-Cruz2
1SaBio, Instituto de Investigación en Recursos Cinegéticos (IREC), CSIC, Universidad de Castilla-La Mancha (UCLM), Junta de Comunidades de Castilla - La Mancha (JCCM), Ciudad Real, Spain.
Frontiers in Physiology
|December 14, 2018
Summary
Subolesin/Akirin proteins are conserved across species, maintaining function and structure. This evolutionary conservation suggests their potential as vaccine antigens against ectoparasites and pathogens.
Area of Science:
- Evolutionary Biology
- Molecular Biology
- Immunology
Background:
- Subolesin/Akirin proteins are conserved across metazoans.
- They regulate diverse biological processes.
- Their evolutionary history and functional conservation are key research areas.
Purpose of the Study:
- Investigate the evolutionary history of Subolesin/Akirin.
- Provide insights into the functional evolution of these regulatory proteins.
- Explore their potential as vaccine antigens for controlling ectoparasite infestations and pathogen infections.
Main Methods:
- Analysis of evolutionary history.
- Examination of protein structure and interactions.
- Functional studies across different species.
Main Results:
- Subolesin/Akirin proteins have conserved sequence, structure, and function.
- Functional conservation is observed in response to pathogen infection and other biological processes.
- Conserved function correlates with protective capacity in vaccine formulations.
Conclusions:
- Subolesin/Akirin proteins exhibit remarkable functional conservation throughout evolution.
- This conservation offers a platform for understanding species-specific adaptations.
- Subolesin/Akirin proteins show promise for developing novel vaccines against arthropod and pathogen species.
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