Related Experiment Video

Updated: Feb 1, 2026

Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions
08:18

Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions

Published on: October 4, 2024

1.5K

Association of vitamin D receptor expression with inflammatory changes and prognosis of asthma

Yanhua Chen1, Tongbai Xu1

  • 1Respiratory Department, Tianjin Hospital of ITCWM Nankai Hospital, Tianjin 300000, P.R. China.

Experimental and Therapeutic Medicine
|December 14, 2018
PubMed

Insights

Vitamin D receptor expression is lower in asthma patients, correlating with increased pro-inflammatory factors like IL-6 and TNF-α. Lower vitamin D receptor levels negatively impact asthma prognosis and lung function recovery.

Area of Science:

  • Immunology
  • Pulmonology
  • Endocrinology

Background:

  • Asthma is a chronic inflammatory airway disease.
  • Vitamin D receptor (VDR) plays a role in immune regulation.
  • The relationship between VDR expression and asthma-related inflammation requires further elucidation.

Purpose of the Study:

  • To investigate the expression level of vitamin D receptor in asthma patients.
  • To analyze the association between VDR expression and inflammatory changes in asthma.
  • To explore the impact of VDR on asthma prognosis and lung function.

Main Methods:

  • Compared VDR mRNA and protein levels in 30 asthma patients and 30 healthy controls using RT-qPCR and Western blot.
  • Measured serum levels of inflammatory factors (IL-6, TNF-α, IL-10, TGF-β) via ELISA.
  • Correlated VDR expression with inflammatory markers and patient prognoses using Pearson analysis.

Main Results:

  • Asthma patients exhibited significantly lower VDR mRNA and protein expression compared to controls (P<0.01).
  • Serum levels of pro-inflammatory cytokines IL-6 and TNF-α were elevated, while anti-inflammatory cytokines IL-10 and TGF-β were reduced in asthma patients (P<0.01).
  • VDR expression negatively correlated with IL-6 and TNF-α, and positively correlated with IL-10 and TGF-β (P<0.05).

Conclusions:

  • Reduced vitamin D receptor expression is associated with heightened inflammation in asthma.
  • VDR expression levels influence asthma prognosis and lung function recovery.
  • Targeting VDR may offer therapeutic potential for asthma management.
Keywords:
asthmainflammationprognosisvitamin D receptor

More Related Videos

Acupuncture in a Rat Model of Asthma07:14

Acupuncture in a Rat Model of Asthma

Published on: August 25, 2020

6.6K
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

32.5K

Related Concept Videos

Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.5K
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.5K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.3K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.1K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.3K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.3K