Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parallel Resonance01:23

Parallel Resonance

558
The parallel RLC circuit is an arrangement where the resistor (R), inductor (L), and capacitor (C) are all connected to the same nodes and, as a result, share the same voltage across them. The parallel RLC circuit is analyzed in terms of admittance (Y), which reflects the ease with which current can flow. The admittance is given by:
558
Parallel Processing01:20

Parallel Processing

716
The brain processes sensory information rapidly due to parallel processing, which involves sending data across multiple neural pathways at the same time. This method allows the brain to manage various sensory qualities, such as shapes, colors, movements, and locations, all concurrently. For instance, when observing a forest landscape, the brain simultaneously processes the movement of leaves, the shapes of trees, the depth between them, and the various shades of green. This enables a quick and...
716
Resistors In Parallel01:23

Resistors In Parallel

6.2K
Resistors are in parallel when one end of all the resistors are connected to a continuous wire of negligible resistance and the other end of all the resistors are also connected to one another through a continuous wire of negligible resistance. In the case of a parallel configuration, the potential drop across each resistor is the same. Current through each resistor can be found using Ohm’s law, I = V/R, where the voltage is constant across each resistor. The sum of the individual currents...
6.2K
Series and Parallel Capacitors01:14

Series and Parallel Capacitors

9.4K
Capacitors, fundamental components in electronic circuits, can be connected in series and/or parallel configurations. Each configuration has different impacts on the overall behavior of the circuit.
First, consider capacitors connected in series to a battery. In this configuration, the plate connected to the battery's positive terminal develops a positive charge, while the plate attached to the negative terminal becomes negatively charged. An equal magnitude of charge is induced on the...
9.4K
Parallel-axis Theorem01:06

Parallel-axis Theorem

8.3K
The parallel-axis theorem provides a convenient and quick method of finding the moment of inertia of an object about an axis parallel to the axis passing through its center of mass. Consider a thin rod as an example. There is a striking similarity between the process of finding the moment of inertia of a thin rod about an axis through its middle, where the center of mass lies, and about an axis through its end using the conventional method. In the conventional method, the concept of linear mass...
8.3K
What is Natural Selection?01:32

What is Natural Selection?

129.0K
Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
129.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Planar Chiral Carbazole-Naphthalene Bisimide Hetero-Cyclophane for Circularly Polarized Delayed Fluorescence.

Angewandte Chemie (International ed. in English)·2026
Same author

The influence of H-bonding network disruption on morphology, structure and autofluorescence of amyloids.

Materials advances·2026
Same author

Fluorescent merocyanines: from fundamental properties to applications as molecular probes, in bioimaging and as emissive dye aggregates.

Chemical Society reviews·2026
Same author

Colour by design: tuning the solid-state emission of coronene bisimide by tailored matrices.

Chemical science·2026
Same author

Enzyme-Like Synthetic Cleft for Light-Driven Water-Oxidation Catalysis Via an Oxide Relay Pathway.

Angewandte Chemie (International ed. in English)·2026
Same author

Distorted Nanographenes by Embedding a Cyclopenta[<i>a</i>]heptalene Core and Multiple Additional Heptagons: Chiral Supramolecular π-Dodecamer and Co-crystal with Fullerenes.

Journal of the American Chemical Society·2026

Related Experiment Video

Updated: Feb 1, 2026

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
05:51

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

Published on: March 17, 2023

2.3K

Selective parallel G-quadruplex recognition by a NIR-to-NIR two-photon squaraine.

Vincenzo Grande1,2, Chia-An Shen1, Marco Deiana3

  • 1Universität Würzburg , Institut für Organische Chemie , Am Hubland , 97074 Würzburg , Germany .

Chemical Science
|December 14, 2018
PubMed
Summary

Researchers developed a new near-infrared fluorescent probe, CAS-C1, that selectively detects parallel G-quadruplex (G4) structures. This probe offers high sensitivity and brightness for advanced biomedical imaging applications.

More Related Videos

An Experimental Protocol for Femtosecond NIR/UV - XUV Pump-Probe Experiments with Free-Electron Lasers
09:49

An Experimental Protocol for Femtosecond NIR/UV - XUV Pump-Probe Experiments with Free-Electron Lasers

Published on: October 23, 2018

16.5K
Using Brain Activation nir-HEG/Q-EEG and Execution Measures CPTs in a ADHD Assessment Protocol
13:09

Using Brain Activation nir-HEG/Q-EEG and Execution Measures CPTs in a ADHD Assessment Protocol

Published on: April 1, 2018

11.0K

Related Experiment Videos

Last Updated: Feb 1, 2026

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
05:51

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

Published on: March 17, 2023

2.3K
An Experimental Protocol for Femtosecond NIR/UV - XUV Pump-Probe Experiments with Free-Electron Lasers
09:49

An Experimental Protocol for Femtosecond NIR/UV - XUV Pump-Probe Experiments with Free-Electron Lasers

Published on: October 23, 2018

16.5K
Using Brain Activation nir-HEG/Q-EEG and Execution Measures CPTs in a ADHD Assessment Protocol
13:09

Using Brain Activation nir-HEG/Q-EEG and Execution Measures CPTs in a ADHD Assessment Protocol

Published on: April 1, 2018

11.0K

Area of Science:

  • Biomedical research
  • Chemical biology
  • Molecular imaging

Background:

  • G-quadruplex (G4) structures are crucial in biological processes.
  • Developing specific probes for G4 conformations is vital for research.
  • Near-infrared (NIR) fluorescence imaging offers deep tissue penetration.

Purpose of the Study:

  • To synthesize and characterize a novel water-soluble NIR amphiphilic squaraine dye, CAS-C1.
  • To evaluate CAS-C1's selective binding and fluorescence properties for G4 conformations.
  • To assess CAS-C1's potential for ultrasensitive two-photon imaging.

Main Methods:

  • Synthesis of the squaraine dye CAS-C1.
  • Spectroscopic analysis of dye-G4 interactions (linear and two-photon).
  • Determination of binding constants and fluorescence quantum yields.

Main Results:

  • CAS-C1 selectively detects parallel G4s over other topologies.
  • High fluorescence quantum yield (Φf ≈ 0.7) and molecular brightness in the NIR region.
  • Nanomolar binding constants (Kb = 10^7 to 10^8 M⁻¹) for parallel G4s.
  • Significant two-photon absorption cross-sections in the second NIR window (λ ≈ 1275 nm).

Conclusions:

  • CAS-C1 is a highly potent and selective binder for parallel G4s.
  • The probe enables ultrasensitive NIR-to-NIR two-photon imaging.
  • CAS-C1 is a promising tool for advanced biomedical research and diagnostics.