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Pregabalin-associated Discontinuation Symptoms: A Case Report
Sadiq Naveed1, Amber E Faquih2, Amna Mohyud Din Chaudhary3
1Psychiatry, KVC Prairie Ridge Psychiatric Hospital, Kansas City, USA.
Pregabalin discontinuation symptoms can occur even with slow tapering. This case report details withdrawal in a 62-year-old patient, emphasizing careful monitoring during dose reduction.
Area of Science:
- Pharmacology
- Neurology
- Psychiatry
Background:
- Pregabalin is a widely prescribed medication for neuropathic pain, seizures, and anxiety disorders.
- Discontinuation symptoms are generally considered mild and self-limiting within a week.
Observation:
- A 62-year-old patient experienced withdrawal symptoms despite a gradual, multi-week tapering schedule of pregabalin.
- The patient's symptoms were noted despite the slow titration, which is typically used to minimize adverse effects.
Findings:
- This case report indicates that even slow tapering of pregabalin may not prevent discontinuation symptoms in all patients.
- The severity and duration of withdrawal can vary, necessitating individualized patient management.
Implications:
- Clinicians should exercise caution and closely monitor patients for withdrawal symptoms during pregabalin tapering, regardless of the titration speed.
- Further research may be needed to identify predictors of pregabalin withdrawal and optimize tapering strategies.
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