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Updated: Feb 1, 2026
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The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies
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Lipocalin-2 in Stroke
Wen-Hai Chou1, Guona Wang1, Varun Kumar1
1Department of Biological Sciences, School of Biomedical Sciences, Kent State University, Kent, OH 44224, USA.
Neuro : Open Journal
|December 14, 2018
Summary
Lipocalin-2 (LCN2) plays a key role in neuroinflammation following stroke. Understanding LCN2
Area of Science:
- Neuroscience
- Immunology
- Biochemistry
Background:
- Stroke is a major cause of adult disability.
- Targeted therapies for stroke remain limited.
- Lipocalin-2 (LCN2) is identified as an acute phase protein involved in post-stroke neuroinflammation.
Purpose of the Study:
- To review current research on Lipocalin-2 (LCN2) in stroke.
- To discuss the specific role of LCN2 in stroke pathophysiology.
Main Methods:
- Literature review of LCN2-related studies in stroke.
- Analysis of LCN2's involvement in neuroinflammation.
Main Results:
- LCN2 is implicated in mediating neuroinflammation after both ischemic and hemorrhagic strokes.
- Emerging evidence highlights LCN2's significant role in stroke.
Conclusions:
- Lipocalin-2 (LCN2) is a critical factor in stroke-induced neuroinflammation.
- Further research into LCN2 may lead to novel therapeutic strategies for stroke.
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