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Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
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Knowledge base toward understanding actionable alterations and realizing precision oncology.

Shiho Takeuchi1,2, Shujiro Okuda3,4

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International Journal of Clinical Oncology
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Interpreting genomic alterations in cancer is crucial for precision medicine. This review discusses knowledge bases and resources needed to implement cancer precision medicine effectively in Japan.

Keywords:
Knowledge baseNext-generation sequencingPrecision oncology

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Area of Science:

  • Oncology
  • Genomics
  • Clinical Diagnostics

Background:

  • Next-generation sequencing (NGS) is used for in vitro diagnostic testing in Japanese cancer care.
  • Molecular alterations guide targeted therapy and investigational drug access for cancer patients.
  • Interpreting genomic alterations is a major challenge for precision medicine in oncology.

Purpose of the Study:

  • To review existing knowledge bases for clinical decision-making in cancer based on genomic events.
  • To identify necessary resources for implementing precision medicine in Japan.
  • To address the limitations of US-based knowledge bases for Japanese clinical practice.

Main Methods:

  • Literature review of current knowledge bases for cancer genomic interpretation.
  • Analysis of differences in drug approvals and clinical trials between the US and Japan.
  • Discussion of resources required for Japanese precision medicine implementation.

Main Results:

  • Existing US-based knowledge bases are not fully applicable to Japan due to differences in approved therapies and clinical trials.
  • There is a need for tailored resources to support clinical decision-making based on cancer genomic data in Japan.

Conclusions:

  • Effective implementation of precision medicine in Japan requires specific knowledge bases and resources.
  • Addressing the bottleneck in genomic alteration interpretation is key to advancing cancer care in Japan.