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Updated: Feb 1, 2026

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Published on: September 28, 2022
In(OTf)3-Catalyzed Cascade Cyclization for Construction of Oxatricyclic Compounds
Wenli Bao1, Yezi Tao1, Jiangqun Cheng1
1Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology , Peking University Shenzhen Graduate School , Shenzhen University Town, Xili, Shenzhen 518055 , China.
Abstract:
A highly diastereoselective cascade cyclization reaction has been developed for establishing a series of oxatricyclic compounds using Chan's diene and simple keto alkynal substrates with only 1 mol % of In(OTf)3 as the catalyst in 82-92% yields. The potential utility of this synthetic strategy has been demonstrated in model studies for the construction the core structures of 1α,8α:4α,5α-diepoxy-4,5-dihydroosmitopsin and cortistatin A.
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