Related Experiment Video
Updated: Feb 1, 2026

In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System
Published on: July 2, 2020
Noninvasive biodegradable nanoparticles-in-nanofibers single-dose ocular insert: in vitro, ex vivo and in vivo
Islam A Khalil1,2, Isra H Ali1, Ibrahim M El-Sherbiny1
1Nanomaterials Lab, Center of Material Science (CMS), Zewail City of Science & Technology, 6th of October, Giza 12578, Egypt.
Aim:
This study involves, for the first time, the development of mucoadhesive biodegradable polymeric-multilayered nanoparticles-in-nanofibers (NPs-in-NFs) matrix as an innovative single-dose noninvasive ocular-insert that could substitute conventional ocular dosage-forms.
Materials & Methods:
Azithromycin-loaded poly(lactic-co-glycolic acid) copolymer/pluronic NPs were developed then incorporated into electrospun polyvinylpyrrolidone NFs, and tested for their efficient treatment of ocular bacterial infection.
Results:
Release and permeation studies proved the ability of the insert to control drug release over 10 days.
Conclusion:
The incorporation of NPs into NFs achieved several other benefits like increasing ocular residence and contact time with conjunctival tissue, accurate dose delivery, sustaining drug release with constant rate, reducing frequency of administration, improving bioavailability along with decreasing incidence of visual and systemic side effects.
More Related Videos
Related Concept Videos
Equivalence: In Vitro and In Vivo Bioequivalence
Drug Product Performance: In Vitro–In Vivo Correlation
Insertion of Single-pass Transmembrane Proteins in the RER
Integral transmembrane proteins possess transmembrane and extra membrane domains. The transmembrane domains are primarily made of 20-25 hydrophobic amino acids arranged in a helical secondary confirmation. These...
Bioavailability Study Design: Single Versus Multiple Dose Studies
Dose Size and Dosing Frequency: Determination Methods
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

