Evolving landscape of the treatment of metastatic clear cell renal cell carcinoma
Related Experiment Video
Updated: Feb 1, 2026
Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
Published on: April 29, 2014
Pooja Ghatalia1, Matthew R Zibelman1, Daniel M Geynisman1
1Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Abstract:
The management of advanced clear cell renal cell carcinoma (RCC) has evolved over the past decade with the introduction of targeted therapies and immune checkpoint inhibitors. Recently, studies of dual checkpoint inhibition and of vascular endothelial growth factor (VEGF) inhibition combined with checkpoint inhibition have shown promising results, adding newer options to the treatment armamentarium for advanced RCC. Specifically, therapies combining checkpoint inhibitors of different classes and combining VEGF inhibitors with checkpoint inhibitors have gained much interest, and results from studies of several other combinations are awaited. These and previously approved treatments offer multiple options to patients with advanced RCC. In this review, we discuss the efficacy and safety results from the pivotal trials of these therapies, how the trial data can guide selection of the most appropriate therapy, and how to consider sequencing therapies in the care of patients with advanced RCC.
Insights
Advanced clear cell renal cell carcinoma (RCC) treatment now includes targeted therapies and immune checkpoint inhibitors. This review discusses new combination therapies, their efficacy, safety, and optimal sequencing for advanced RCC patients.
Area of Science:
- Oncology
- Nephrology
Background:
- Advanced clear cell renal cell carcinoma (RCC) management has significantly advanced.
- Newer treatment options include targeted therapies and immune checkpoint inhibitors.
Purpose of the Study:
- To review the efficacy and safety of current and emerging therapies for advanced RCC.
- To guide the selection and sequencing of treatments for advanced RCC.
Main Methods:
- Review of pivotal clinical trial data for targeted therapies and immune checkpoint inhibitors.
- Analysis of combination therapies including dual checkpoint inhibition and VEGF inhibition with checkpoint inhibition.
Main Results:
- Combination therapies, including dual checkpoint inhibition and VEGF inhibition with checkpoint inhibition, show promising results.
- Multiple treatment options are available for advanced RCC, with more combinations under investigation.
Conclusions:
- Current treatment landscape offers diverse options for advanced RCC.
- Understanding trial data is crucial for selecting and sequencing therapies effectively.
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