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Optimization of PET reconstruction algorithm, SUV thresholding algorithm and PET acquisition time in clinical
Sara Strandberg1, Armin Hashemi1, Jan Axelsson1
1Department of Radiation Sciences, Diagnostic Radiology, Umea University, Umea, Sweden.
Plos One
|December 14, 2018
Summary
The SharpIR 42% reconstruction algorithm provides the most accurate quantitative data for 11C-acetate PET/CT in high-risk prostate cancer staging. Shorter acquisition times of two minutes per bed position maintain image quality and quantitative accuracy.
Area of Science:
- Nuclear Medicine
- Radiology
- Oncology
Background:
- 11C-acetate (ACE)-PET/CT is crucial for staging high-risk prostate cancer.
- PET image reconstruction algorithms, like VUEPointHD ViP (VPHD) and VUEPoint HD Sharp IR (SharpIR), impact quantitative accuracy.
- Resolution recovery in algorithms like SharpIR is expected to improve SUVmax, SUVmean, and FTV compared to standard OSEM.
Purpose of the Study:
- To determine the optimal reconstruction algorithm for ACE-PET/CT in prostate cancer.
- To identify the best SUV threshold for delineating functional tumor volumes (FTV).
- To optimize PET acquisition time without compromising image quality or quantitative results.
Main Methods:
- ACE-PET/CT data from 16 high-risk prostate cancer patients were reconstructed using VPHD and SharpIR.
- Pelvic lymph nodes and prostate glands were delineated using 42% and estimated SUV thresholds.
- SUVmax, SUVmean, FTV, and total lesion uptake were measured; acquisition times (1, 2, 4 minutes) were evaluated.
Main Results:
- SharpIR yielded higher SUVmax/SUVmean and lower FTV than VPHD, with SharpIR 42% showing better correlation with structural tumor volumes.
- Longer acquisition times increased FTV, with one minute per bed position showing the most pronounced difference and highest noise.
- SUV parameters remained unaffected by varying acquisition times; SharpIR 42% demonstrated improved recovery coefficients in phantom studies.
Conclusions:
- SharpIR 42% reconstruction with a 42% SUV threshold offers the most accurate quantitative assessment (SUVmax, SUVmean, FTV, total lesion uptake) for ACE-PET/CT in prostate cancer.
- Acquisition time can be reduced to two minutes per bed position without sacrificing image quality or quantitative accuracy.
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