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Related Experiment Video

Updated: Feb 1, 2026

Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes
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Genetically modified pigs are protected from classical swine fever virus.

Zicong Xie1, Daxin Pang1, Hongming Yuan1

  • 1Jilin Provincial Key Laboratory of Animal Embryo Engineering, Institute of Zoonosis, College of Animal Sciences, Jilin University, 130062, Changchun, Jilin Province, People's Republic of China.

Plos Pathogens
|December 14, 2018
PubMed
Summary

Researchers developed transgenic pigs resistant to Classical swine fever (CSF) using RNA interference and CRISPR/Cas9 technology. These pigs effectively combat the virus, reducing mortality and economic losses in the swine industry.

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Area of Science:

  • Veterinary Virology
  • Genetic Engineering
  • Animal Biotechnology

Background:

  • Classical swine fever (CSF) poses a significant economic threat to the global swine industry due to its high morbidity and mortality.
  • Current control strategies for CSF have limited success in eradicating the virus from endemic regions.

Purpose of the Study:

  • To develop a novel strategy for conferring resistance to Classical swine fever virus (CSFV) in pigs.
  • To assess the efficacy of antiviral small hairpin RNAs (shRNAs) delivered via CRISPR/Cas9-mediated gene editing in pigs.

Main Methods:

  • Selection of antiviral shRNAs targeting CSFV.
  • CRISPR/Cas9-mediated knock-in of shRNAs into the porcine Rosa26 (pRosa26) locus.
  • Production of anti-CSFV transgenic (TG) pigs using somatic nuclear transfer (SCNT).
  • In vitro and in vivo CSFV challenge assays to evaluate disease resistance.

Main Results:

  • Transgenic pigs effectively limited CSFV replication following viral challenge.
  • TG pigs exhibited reduced CSFV-associated clinical signs and mortality compared to controls.
  • Disease resistance was stably transmitted to the F1-generation offspring.

Conclusions:

  • RNA interference (RNAi) combined with CRISPR/Cas9 technology provides a viable method for producing animals with enhanced resistance to viral pathogens.
  • The developed anti-CSFV transgenic pigs offer a promising tool for reducing economic losses associated with CSF.
  • This antiviral strategy holds potential for future applications in combating viral diseases in livestock.