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Updated: Feb 1, 2026

Drosophila Courtship Conditioning As a Measure of Learning and Memory
Published on: June 5, 2017
Ecdysis triggering hormone receptors regulate male courtship behavior via antennal lobe interneurons in Drosophila
Sonali A Deshpande1, Matthew Meiselman2, Robert H Hice1
1Department of Entomology, University of California, Riverside, CA 92521, United States.
Abstract:
Ecdysis triggering hormone receptors (ETHR) regulate the behavioral sequence necessary for cuticle shedding. Recent reports have documented functions for ETHR signaling in adult Drosophila melanogaster. In this study, we report that ETHR silencing in local interneurons of the antennal lobes and fruitless neurons leads to sharply increased rates of male-male courtship. RNAseq analysis of ETHR knockdown flies reveals differential expression of genes involved in axon guidance, courtship behavior and chemosensory functions. Our findings indicate an important role for ETHR in regulation of Drosophila courtship behavior through chemosensory processing in the antennal lobe.
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