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Autoimmune and angiogenic biomarkers in autoimmune atherosclerosis

Emese Balogh1, Anita Pusztai2, Attila Hamar2

  • 1Division of Rheumatology, Department of Medicine, University of Debrecen, Faculty of Medicine, Debrecen, Hungary; Centre for Arthritis and Rheumatic Diseases, St. Vincent's University Hospital, Dublin, Ireland.

Clinical Immunology (Orlando, Fla.)
|December 14, 2018
PubMed

Insights

Several factors contribute to accelerated atherosclerosis in rheumatic diseases. Multi-biomarker profiles may best track vascular damage and outcomes in these patients.

Area of Science:

  • Rheumatology
  • Cardiovascular Pathology
  • Biomarker Discovery

Background:

  • Autoimmune rheumatic diseases are associated with accelerated atherosclerosis.
  • Inflammatory, proteolytic, angiogenic, and bone-associated factors are implicated in this process.

Purpose of the Study:

  • To identify potential biomarkers for vascular pathology in rheumatic diseases.
  • To evaluate the utility of these biomarkers in monitoring vascular damage and outcomes.

Main Methods:

  • Review of existing literature on inflammatory, proteolytic, angiogenic, and bone-associated factors in rheumatic disease-related atherosclerosis.
  • Analysis of the potential role of these factors as biomarkers.

Main Results:

  • Multiple factors, including inflammatory, proteolytic, angiogenic, and bone-associated mediators, are involved in accelerated atherosclerosis in rheumatic diseases.
  • These factors show potential as indicators of vascular pathology.

Conclusions:

  • Biomarkers are crucial for monitoring vascular damage and outcomes in rheumatic diseases.
  • Multi-biomarker profiles are likely superior to single markers for comprehensive assessment.

Keywords:
AngiogenesisAutoimmune atherosclerosisAutoimmunityBiomarkersCardiovascular disease

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