Related Experiment Video

Updated: Feb 1, 2026

Author Spotlight: Shear Assay Protocol for the Determination of Single-Cell Material Properties
08:19

Author Spotlight: Shear Assay Protocol for the Determination of Single-Cell Material Properties

Published on: May 19, 2023

2.4K

A shear assay study of single normal/breast cancer cell deformation and detachment from poly-di-methyl-siloxane

C J Ani1, J D Obayemi2, V O Uzonwanne2

  • 1Department of Theoretical and Applied Physics, African University of Science and Technology, Km 10, Airport Road, Galadimawa, Abuja, Federal Capital Territory, Nigeria; Department of Physics, Salem University, Km 16, PMB 1060, Lokoja, Kogi State, Nigeria.

Journal of the Mechanical Behavior of Biomedical Materials
|December 14, 2018
PubMed

Keywords:
Cell deformation and detachmentInterfacial fractureShear assay techniqueVinculin pull-outViscoelastic cell deformation

More Related Videos

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

18.9K
Micropatterned Surfaces to Study Hyaluronic Acid Interactions with Cancer Cells10:13

Micropatterned Surfaces to Study Hyaluronic Acid Interactions with Cancer Cells

Published on: December 22, 2010

15.6K

Related Concept Videos

Normal and Shear Force01:14

Normal and Shear Force

When a beam is subjected to different loads, such as weight, pressure, or other external forces, internal forces are generated within the beam. These forces can have a significant impact on the overall stability and strength of the structure. Engineers use various methods to analyze and determine the magnitude and direction of these internal forces. One common technique used to determine internal forces in beams is the method of sections. This method involves considering an imaginary point or...
3.3K
Plastic Deformations of Members with a Single Plane of Symmetry01:21

Plastic Deformations of Members with a Single Plane of Symmetry

When a structural member undergoes plastic deformation due to bending, it is crucial to understand the position of the neutral axis and the stress distribution. This member, characterized by a single plane of symmetry, exhibits a uniform stress distribution, with negative stress above the neutral axis and positive stress below. Notably, the neutral axis does not align with the centroid of the cross-section. This misalignment is typical in cases where the cross-section is not rectangular or...
371
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
14.9K
Plastic Deformations01:19

Plastic Deformations

Plastic deformation represents a fundamental concept in materials science, which explains the irreversible change in the shape of a material when it experiences stress beyond its elastic capability. This phenomenon is important in structural engineering, especially in designing and analyzing cantilever beams—structures that are securely fixed at one end and bear loads at the opposite end. When these beams are subjected to loads within their elastic range, they will return to their...
465
Plastic Deformations01:14

Plastic Deformations

It is essential to understand how structural members behave under plastic deformation when the bending stress exceeds the material's yield strength. This state of deformation permanently alters the shape of the member, in contrast to the linear elastic behavior observed before yielding. The strain at any point in the member is expressed in terms of maximum strain. Notably, the neutral axis, which coincides with the centroid during elastic bending, shifts away from the centroid under plastic...
443
Cell-surface Signaling01:21

Cell-surface Signaling

Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.
54.4K