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Insight into the role of TRAIL in liver diseases

Wei Jiang1, Dong-Bo Wu1, Si-Yu Fu1

  • 1Center of Infectious Diseases, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Wuhou District, Chengdu, Sichuan Province, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|December 14, 2018
PubMed

Insights

TNF-related apoptosis inducing ligand (TRAIL) shows promise for treating liver cancer by selectively inducing cancer cell death. This review explores TRAIL's complex roles in various liver diseases, including viral hepatitis and fatty liver disease.

Area of Science:

  • Oncology
  • Hepatology
  • Immunology

Background:

  • TNF-related apoptosis inducing ligand (TRAIL) selectively induces apoptosis in tumor cells, sparing normal tissues.
  • TRAIL is implicated in hepatocellular carcinoma (HCC) pathogenesis and has therapeutic potential.
  • TRAIL's role in liver injury, including viral hepatitis and fatty liver disease, is complex and requires further clarification.

Purpose of the Study:

  • To review recent advancements in understanding TRAIL's function.
  • To explore TRAIL's therapeutic applications in HCC.
  • To elucidate TRAIL's multifaceted roles in viral hepatitis, fatty liver disease, liver fibrosis, and cirrhosis.

Main Methods:

  • Literature review of recent studies on TRAIL.
  • Analysis of TRAIL's apoptotic signaling pathways.
  • Synthesis of data on TRAIL's involvement in various liver conditions.

Main Results:

  • TRAIL effectively induces apoptosis in various cancer cells, including HCC.
  • TRAIL plays a significant role in the pathogenesis of viral hepatitis and fatty liver diseases.
  • Conflicting evidence exists regarding TRAIL's precise effects in liver injury, necessitating further investigation.

Conclusions:

  • TRAIL is a promising therapeutic target for HCC.
  • Understanding TRAIL's dual role in liver injury is crucial for developing effective treatments.
  • Further research is needed to fully elucidate TRAIL's complex mechanisms in liver diseases.
Keywords:
ApoptosisHepatocellular carcinomaLiver diseaseTRAIL

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