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Inflammatory demyelinating neuropathies with focal segmental glomerulosclerosis: Two case reports
Yuhe Mao1,2, Min Zhang2, Shaojun Liu2
1Department of Nephrology, Meizhou People's Hospital, Meizhou Hospital Affiliated to Sun Yat-Sen University, Meizhou, Guangdong Province.
Medicine
|December 15, 2018
Summary
Two patients with focal segmental glomerulosclerosis (FSGS) also had inflammatory demyelinating polyneuropathies, Guillain-Barré syndrome (GBS) or chronic inflammatory demyelinating polyneuropathy (CIDP). This suggests shared autoimmune mechanisms in these distinct conditions.
Area of Science:
- Nephrology
- Neurology
- Immunology
Background:
- Focal segmental glomerulosclerosis (FSGS) and inflammatory demyelinating neuropathies like Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP) are autoimmune disorders.
- The potential for a common underlying pathogenesis warrants investigation.
Observation:
- Two unique cases of FSGS are presented, one co-occurring with GBS and the other with CIDP.
- Patients presented with distinct neurological and renal symptoms, including limb paresthesia, weakness, and edema.
Findings:
- Diagnostic workup confirmed FSGS in both patients via renal biopsy.
- Nerve conduction velocity tests and CSF studies supported GBS in the first patient, while the second was diagnosed with CIDP.
Implications:
- The co-occurrence suggests synergistic autoimmune mechanisms, possibly involving cross-reactive antigens or molecular mimicry.
- Further research into the shared pathogenesis of these multisystemic autoimmune diseases is crucial for understanding FSGS.
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