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Chaperoning the Mononegavirales: Current Knowledge and Future Directions
Victor Latorre1, Florian Mattenberger2, Ron Geller3
1Institute for Integrative Systems Biology (I2SysBio), Universitat de Valencia-CSIC, 46980 Valencia, Spain. Victor.Latorre-Rosello@uv.es.
Viruses
|December 15, 2018
Summary
Viruses in the order Mononegavirales rely on cellular molecular chaperones for protein folding. Targeting these chaperones could lead to new antiviral therapies against mononegaviruses.
Area of Science:
- Virology
- Molecular Biology
- Biochemistry
Background:
- The order Mononegavirales includes many human health-relevant viruses.
- Limited vaccines and antivirals exist for these viruses.
- Viruses depend on host cell machinery for replication.
Purpose of the Study:
- To review interactions between Mononegavirales and cellular chaperones.
- To identify knowledge gaps in this area.
- To explore chaperone inhibitors as potential antivirals.
Main Methods:
- Literature review of scientific publications.
- Analysis of host-virus interactions.
- Discussion of therapeutic strategies.
Main Results:
- Mononegavirales viruses interact with cellular molecular chaperones.
- Chaperones are crucial for viral protein folding and homeostasis.
- Specific chaperone-host interactions are key for viral replication.
Conclusions:
- Cellular chaperones are essential for Mononegavirales.
- Targeting chaperones offers a promising antiviral strategy.
- Further research into chaperone inhibitors is warranted.
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