Related Experiment Video

Updated: Feb 1, 2026

Examining BCL-2 Family Function with Large Unilamellar Vesicles
08:35

Examining BCL-2 Family Function with Large Unilamellar Vesicles

Published on: October 5, 2012

8.4K

Bcl-2 Inhibition to Overcome Resistance to Chemo- and Immunotherapy

Marilina García-Aranda1, Elisabet Pérez-Ruiz2, Maximino Redondo3

  • 1Research Unit, REDISSEC, Hospital Costa del Sol, Autovía A-7, km 187, 29603 Marbella, Málaga, Spain. marilina@hcs.es.

International Journal of Molecular Sciences
|December 15, 2018
PubMed

Insights

Bcl-2 over-expression is a hallmark of cancer, contributing to resistance against cancer treatments. Bcl-2 inhibitors show promise in overcoming this resistance to chemotherapy and immunotherapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Death Research

Background:

  • Cancer is a major global health challenge, necessitating novel therapeutic targets.
  • Bcl-2 over-expression is recognized as a key factor in cancer development and treatment resistance.
  • Understanding programmed cell death pathways is crucial for effective cancer therapy.

Purpose of the Study:

  • To review programmed cell death pathways.
  • To examine the role of Bcl-2 family proteins in apoptosis resistance.
  • To explore the therapeutic potential of Bcl-2 inhibitors in overcoming treatment resistance.

Main Methods:

  • Literature review of programmed cell death pathways.
  • Analysis of Bcl-2 family member functions in apoptosis.
  • Evaluation of Bcl-2 inhibition strategies against chemo- and immunotherapy resistance.

Main Results:

  • Bcl-2 family proteins play a critical role in regulating apoptosis.
  • Over-expression of Bcl-2 confers resistance to various anti-cancer treatments.
  • Bcl-2 inhibition strategies demonstrate potential in sensitizing cancer cells to therapy.

Conclusions:

  • Targeting Bcl-2 offers a promising strategy to enhance cancer treatment efficacy.
  • Bcl-2 inhibitors may overcome resistance to chemotherapy and immunotherapy.
  • Further research into Bcl-2 pathways and inhibitors is warranted for clinical application.
Keywords:
Bcl-2apoptosiscancerchemotherapyimmunotherapyinhibitionresistance

More Related Videos

Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis EAE Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge08:38

Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis EAE Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge

Published on: April 9, 2012

21.0K
Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy06:51

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

16.0K

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.9K
Feedback Inhibition00:46

Feedback Inhibition

Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
57.1K
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems01:22

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

Body:Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug...
210
Resistivity01:22

Resistivity

When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
Resistance01:19

Resistance

When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.0K
Enzyme Inhibition01:30

Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.
92.4K