Endothelial Contributions to Zebrafish Heart Regeneration
Related Experiment Video
Updated: Feb 1, 2026

An Assay for Lateral Line Regeneration in Adult Zebrafish
Published on: April 8, 2014
Cristina E Fernandez1,2, Melanie Bakovic3, Ravi Karra4,5
1Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. cef19@duke.edu.
Abstract:
Studies over the past two decades have shown heart regeneration in zebrafish to be a dynamic process, choreographed by multiple cell types. In particular, recent work has identified revascularization of the wound to be a sentinel event during heart regeneration. The cardiac endothelium has emerged as a key orchestrator of heart regeneration, influencing cardiomyocyte hyperplasia and tissue morphogenesis. Here, we review how the coronary vasculature regenerates after injury, how signaling pathways link the cardiac endothelium to heart regeneration, and how understanding these signaling dynamics can lead to targeted therapies for heart regeneration.
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