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The Signaling Network Controlling C. elegans Vulval Cell Fate Patterning.

Hanna Shin1, David J Reiner2,3

  • 1Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA. hshin2@medicine.tamhsc.edu.

Journal of Developmental Biology
|December 15, 2018
PubMed
Summary

Epidermal growth factor (EGF) from the Anchor Cell patterns C. elegans vulval precursor cells into three distinct fates. Signaling networks exhibit plasticity during cell differentiation, revealing key developmental biology principles.

Keywords:
DSLEGFEGFRMAP kinaseNotchRafRalRalGEFRassignal transduction

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Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Genetics

Background:

  • The Anchor Cell secretes Epidermal Growth Factor (EGF) to pattern vulval precursor cells in *C. elegans*.
  • Six equipotent vulval precursor cells adopt precise fates with high fidelity.
  • Core and modulatory signaling cascades form a dynamic network during cell differentiation.

Purpose of the Study:

  • To review the historical developmental manipulations and genetic experiments that elucidated vulval cell fate patterning.
  • To discuss principles of signal transduction and developmental biology derived from these studies.

Main Methods:

  • Review of classical developmental manipulations in *C. elegans*.
  • Analysis of molecular genetics experiments.
  • Synthesis of findings on signaling networks and cell fate determination.

Main Results:

  • Detailed understanding of EGF signaling in patterning vulval precursor cells.
  • Identification of a signaling network with plasticity during cell differentiation.
  • Elucidation of the transition from naive to terminally differentiated states.

Conclusions:

  • The *C. elegans* vulva development system provides a model for understanding cell fate patterning and signal transduction.
  • Signaling network plasticity is crucial for precise cell fate acquisition.
  • Studies in this system have yielded fundamental principles in developmental biology.