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Updated: Feb 1, 2026

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
Allelic variation of the serotonin transporter gene polymorphic region in apes
Miho Inoue-Murayama1, Youko Niimi1, Osamu Takenaka2
1Department of Biological Diversity and Resources, Faculty of Agriculture, Gifu University, Gifu, Japan.
Abstract:
To assess the change of serotonin transporter (5-HTT) gene-linked polymorphic region that has occurred during the process of hominization, we examined the allelic variation of 5-HTT gene-linked polymorphic region (5-HTTLPR) in anthropoid apes such as chimpanzees, gorillas, orang-utans, and gibbons, and determined the DNA sequences of the alleles in each species. All chimpanzees examined shared only the 17.5 repeat allele, while polymorphism was observed in the other apes and the 16 and 20 repeat alleles were most frequent in gorillas and orang-utans, respectively. 5-HTTLPR was highly polymorphic in gibbons and the 17 and 23 repeat alleles were most common among 5 alleles. Alleles with extra-long repeated (22 and 23) sequences were found in orang-utans and gibbons, and the alleles of these Asian apes were similar to the rhesus monkey allele.
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