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Related Experiment Video

Updated: Feb 1, 2026

Organotypic Culture Method to Study the Development Of Embryonic Chicken Tissues
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The temporal expression patterns of brain transcriptome during chicken development and ageing.

Zhongxian Xu1, Tiandong Che1, Feng Li2

  • 1Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.

BMC Genomics
|December 15, 2018
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Summary

This study maps chicken brain transcriptome dynamics across development and aging, revealing age-dependent gene expression patterns. Key findings include declining developmental genes and rising immune response genes with age.

Keywords:
Chicken brainDevelopment and ageingTemporal expression patternsTranscriptome

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Area of Science:

  • Genomics
  • Neuroscience
  • Developmental Biology

Background:

  • Mammalian brain development and aging transcriptional profiles are known.
  • Global transcriptome expression patterns in the chicken brain remain unexplored.
  • This study addresses this gap by investigating temporal expression in the female chicken cerebrum.

Purpose of the Study:

  • To systematically investigate temporal expression profiles of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs).
  • To explore age-dependent gene expression patterns in the chicken brain.
  • To predict the biological functions of lncRNAs and understand regulatory mechanisms.

Main Methods:

  • Analysis of transcriptome data across 8 developmental and adult stages in female chicken cerebrum.
  • Identification of putative lncRNAs and mRNAs.
  • Tracking age-dependent genes and co-expression network analysis for lncRNA function prediction.

Main Results:

  • Identified 39,907 putative lncRNAs and 14,558 mRNAs.
  • Observed progressive decay in genes related to development, synapses, and axons with age.
  • Found up-regulation of immune response genes in aging chicken brains.

Conclusions:

  • The findings suggest changes in transcriptional network regulation during chicken brain aging.
  • Identified potential non-coding RNA gene candidates for future research.
  • Provides insights into molecular mechanisms of chicken development and aging, and vertebrate brain evolution.