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Contemporary patient-tailored treatment strategies against high risk and relapsed or refractory multiple myeloma

Fatih M Uckun1, Sanjive Qazi2, Taner Demirer3

  • 1Immuno-Oncology Program, Ares Pharmaceuticals, St. Paul, MN 55110, USA; Norris Comprehensive Cancer Center and Childrens Center for Cancer and Blood Diseases, University of Southern California Keck School of Medicine (USC KSOM), Los Angeles, CA 90027, USA.

Ebiomedicine
|December 15, 2018
PubMed

Insights

Chemotherapy resistance causes multiple myeloma recurrence. New targeted therapies, like BCMA-specific CAR-T cells, offer hope for relapsed/refractory patients.

Area of Science:

  • Oncology
  • Hematology
  • Immunotherapy

Background:

  • Chemotherapy resistance is a primary cause of multiple myeloma (MM) recurrence, significantly impacting patient survival.
  • Relapsed and/or refractory (R/R) MM presents an urgent unmet medical need, necessitating novel therapeutic approaches.
  • Personalized medicine strategies are emerging to combat drug resistance in MM.

Purpose of the Study:

  • To review emerging personalized treatment strategies targeting molecular pathways in multiple myeloma.
  • To highlight novel therapeutics in the clinical pipeline for overcoming drug resistance.
  • To discuss the potential of cell-based therapies, such as CAR-T cells, in managing R/R MM.

Main Methods:

  • Review of current literature on targeted therapies for multiple myeloma.
  • Analysis of clinical pipeline data for novel anti-MM agents.
  • Evaluation of the efficacy of B-cell maturation antigen (BCMA)-specific CAR-T cell therapy in R/R MM.

Main Results:

  • Several targeted therapeutics, including protein inhibitors, antibodies, and cell therapies, are in development.
  • BCMA-specific CAR-T cell platforms demonstrate promising activity in heavily pretreated R/R MM patients.
  • Personalized medicine offers renewed hope for high-risk and R/R MM patients.

Conclusions:

  • Targeted therapies represent a significant advancement in overcoming chemotherapy resistance in multiple myeloma.
  • CAR-T cell therapy targeting BCMA shows particular promise for refractory MM.
  • The era of personalized medicine is improving outcomes for patients with relapsed or refractory multiple myeloma.
Keywords:
BiotherapyImmuno-oncologyImmunotherapyMultiple myelomaPersonalized medicineStem cell transplantation

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