Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Design Example: Application of Archimedes' Principle01:11

Design Example: Application of Archimedes' Principle

838
Archimedes' principle is fundamental in analyzing the buoyant force and stability of floating bodies. In this example, a wooden block with a rectangular section floats in seawater. Based on the block's dimensions, its specific gravity and the specific weight of seawater are used to find the volume of water displaced and the center of buoyancy.
The volume of seawater displaced by the block is determined by first calculating the block's weight. This is done by multiplying the...
838
Lagging Strand Synthesis01:59

Lagging Strand Synthesis

61.3K
During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
61.3K
Displacement Current01:19

Displacement Current

3.8K
Ampère's law, in its usual form, does not work in places where the current changes with time and is not steady. Thus, Maxwell suggested including an additional contribution, called the displacement current, Id, to the real conduction current I.
3.8K
Position and Displacement01:31

Position and Displacement

25.8K
The position of an object defines its location relative to a convenient frame of reference at any particular time. A frame of reference is an arbitrary set of axes from which the position and motion of an object are described. Earth is often used as a frame of reference, and we often describe the position of an object as it relates to stationary objects on Earth. For example, a rocket launch could be described in terms of the position of the rocket with respect to Earth as a whole. On the other...
25.8K
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

14.7K
The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
14.7K
The Uncertainty Principle04:08

The Uncertainty Principle

31.8K
Werner Heisenberg considered the limits of how accurately one can measure properties of an electron or other microscopic particles. He determined that there is a fundamental limit to how accurately one can measure both a particle’s position and its momentum simultaneously. The more accurate the measurement of the momentum of a particle is known, the less accurate the position at that time is known and vice versa. This is what is now called the Heisenberg uncertainty principle. He...
31.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Agnostic material classification using differential de Bruijn graphs of DNA imprints.

bioRxiv : the preprint server for biology·2026
Same author

The Origin of Life in the Light of Evolution.

ArXiv·2026
Same author

Overestimating zero-shot fitness prediction: Broad benchmarks mask local failures and practical limitations.

bioRxiv : the preprint server for biology·2026
Same author

Integrating Transcription Factors with Electrochemical Pendulum Bioanalysis for Hormone Detection.

Journal of the American Chemical Society·2026
Same author

Fieldable isothermal nucleic acid test for rapid semi-quantitative visual readout of enterococci in recreational waters.

PeerJ·2026
Same author

Validation and analysis of 12,000 AI-driven CAR-T designs in the <i>Bits to Binders</i> competitions.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Feb 1, 2026

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography
11:05

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Published on: October 25, 2018

8.0K

Effective design principles for leakless strand displacement systems.

Boya Wang1, Chris Thachuk2, Andrew D Ellington3

  • 1Electrical and Computer Engineering, University of Texas at Austin, Austin, TX 78712.

Proceedings of the National Academy of Sciences of the United States of America
|December 15, 2018
PubMed
Summary

Researchers developed a new method using logical redundancy to significantly reduce errors in DNA strand displacement systems. This innovation enhances the reliability of molecular systems for various applications.

Keywords:
DNA strand displacement cascadesleakmolecular programmingrobustness

More Related Videos

A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump
09:04

A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump

Published on: June 1, 2022

3.7K
Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
07:50

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

14.9K

Related Experiment Videos

Last Updated: Feb 1, 2026

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography
11:05

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Published on: October 25, 2018

8.0K
A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump
09:04

A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump

Published on: June 1, 2022

3.7K
Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
07:50

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

14.9K

Area of Science:

  • Molecular Systems Engineering
  • Synthetic Biology
  • Biochemical Engineering

Background:

  • Artificially designed molecular systems offer programmable behaviors for diverse scientific fields.
  • Achieving robustness to errors in synthetic molecular systems, akin to biological pathways, remains a significant challenge.
  • DNA strand displacement is a versatile tool for cell-free biochemical networks, but susceptible to undesired triggering (leak).

Purpose of the Study:

  • To investigate a design principle for reducing leak in DNA strand displacement cascades.
  • To enhance the sensitivity and reliability of molecular information processing systems.
  • To implement error correction strategies inspired by electrical engineering in biochemical systems.

Main Methods:

  • Employed logical redundancy to increase the energy penalty for leak reactions.
  • Experimentally tested two levels of leak reduction on a core 'translator' component.
  • Constructed a nine-step translator cascade and a 10-translator logic OR gate circuit.

Main Results:

  • The high-redundancy scheme resulted in immeasurable leak, even at significantly higher concentrations.
  • Demonstrated effective leak reduction in a complex nine-step strand displacement cascade.
  • Successfully built a logic OR gate circuit using 10 translators, showcasing scalability.

Conclusions:

  • Logical redundancy is an effective strategy for minimizing leak in DNA strand displacement systems.
  • The developed design principle significantly improves the robustness and reliability of molecular computing components.
  • This approach enables the construction of complex, low-leak biochemical networks for advanced applications.