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Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
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Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Published on: September 30, 2019

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Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical

Brendan Farrell1, Alexander L Breeze2

  • 1Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K.

Biochemical Society Transactions
|December 15, 2018
PubMed

Insights

Fibroblast growth factor receptors (FGFRs) are vital for development and tissue repair. Dysregulated FGFR signaling drives cancers and developmental disorders, making them key pharmaceutical targets for new therapies.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Oncology

Background:

  • Fibroblast growth factor receptors (FGFRs) are receptor tyrosine kinases crucial for embryonic development, metabolism, tissue homeostasis, and wound repair.
  • FGFR signaling pathways regulate cell growth, proliferation, and differentiation.
  • Dysregulation of FGFRs, through overexpression, mutations, or gene fusions, is implicated in various human cancers and developmental disorders like hypochondroplasia and achondroplasia.

Purpose of the Study:

  • To review key research findings on fibroblast growth factor receptor (FGFR) activation and regulation over the past two decades.
  • To summarize current therapeutic intervention strategies targeting FGFR aberrations.
  • To highlight the importance of understanding FGFR structure and mechanism for effective drug development.

Main Methods:

  • Literature review of research findings from the last 20 years.
  • Synthesis of information on FGFR signaling pathways.
  • Analysis of therapeutic strategies for FGFR-related diseases.

Main Results:

  • FGFRs play critical roles in multiple biological processes.
  • Aberrant FGFR signaling is a common driver in oncogenesis and developmental dysplasias.
  • Multiple FGFR-targeting drugs are currently in clinical trials.

Conclusions:

  • FGFRs are significant pharmaceutical targets due to their roles in cancer and developmental disorders.
  • A comprehensive understanding of FGFR activation and regulation is essential for developing effective therapies.
  • Ongoing research and clinical trials show promise for treating FGFR-driven diseases.
Keywords:
drug discovery and designfibroblast growth factor receptorsreceptor tyrosine kinasesstructural biology

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