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Quantity and Reporting Quality of Kidney Research
Markos Kyriakos Tomidis Chatzimanouil1, Louise Wilkens1, Hans-Joachim Anders2
1Division of Nephrology, Medizinische Klinik and Poliklinik IV, Klinikum der Universität München, Ludwig Maximilians University München, Munich, Germany.
Journal of the American Society of Nephrology : JASN
|December 15, 2018
Summary
Nephrology research is growing but still lags behind other fields. While clinical trial reporting quality has improved, significant data reporting deficits persist in preclinical kidney studies, requiring further enhancement.
Area of Science:
- Nephrology
- Medical Research
Background:
- Previous reports indicated a low number and suboptimal quality of nephrology clinical trials.
- The quantity and quality of preclinical kidney research had not been systematically assessed.
Purpose of the Study:
- To systematically review and evaluate the trends in the number and reporting quality of clinical and preclinical kidney research.
- To assess improvements and persistent deficits in reporting based on CONSORT and ARRIVE guidelines.
Main Methods:
- Systematic review of randomized clinical trials (1966-2017) and preclinical studies (1945-2017).
- Reporting quality analysis of 118 clinical trial reports and 135 preclinical studies across selected years (1996, 2006, 2016).
- Evaluation based on CONSORT and ARRIVE guideline criteria.
Main Results:
- Annual clinical kidney trial reports doubled between 2004-2014; focus includes hypertension, CKD, ESRD, AKI.
- Clinical trial reporting quality shows improvement, but issues with design, randomization, and intention-to-treat analysis persist.
- Preclinical kidney study numbers remain low; reporting quality shows substantial deficits with little improvement over 20 years.
Conclusions:
- Nephrology studies are increasing but trail other medical fields.
- Data reporting quality in kidney research, particularly in preclinical studies, needs significant improvement.
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