Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Human cadaveric growth hormone batches linked to Creutzfeldt-Jakob disease transmission also contained amyloid-beta seeds. This study experimentally confirms that these contaminated hormone batches can transmit Alzheimer's disease pathology.
Area Of Science
- Neuroscience
- Neuropathology
- Infectious Diseases
Background
- Individuals treated with cadaver-derived human growth hormone (c-hGH) for Creutzfeldt-Jakob disease (CJD) showed unusual amyloid-beta (Aβ) deposits.
- Previous observations suggested c-hGH batches might be contaminated with both prions and Aβ seeds, but causality remained unproven.
Purpose Of The Study
- To investigate the potential for iatrogenic transmission of amyloid-beta (Aβ) pathology via contaminated human cadaveric pituitary-derived growth hormone (c-hGH).
- To biochemically analyze archived c-hGH batches for the presence of Aβ seeds and assess their seeding potential in vivo.
Main Methods
- Archived c-hGH vials from patients with iatrogenic CJD (iCJD) and Aβ pathology were identified and analyzed.
- Biochemical assays quantified Aβ40, Aβ42, and tau proteins in the c-hGH samples.
- The capacity of the analyzed c-hGH material to seed Aβ pathology was tested in mice genetically engineered to express human amyloid precursor protein.
Main Results
- Certain archived c-hGH batches were found to contain substantial levels of Aβ40, Aβ42, and tau proteins.
- Inoculation of this c-hGH material into mice induced the formation of Aβ plaques and cerebral Aβ-amyloid angiopathy.
- These findings experimentally confirm the presence of Aβ seeds in archived c-hGH.
Conclusions
- The study provides experimental evidence supporting the hypothesis of iatrogenic transmission of Aβ pathology via contaminated c-hGH.
- The findings have significant implications for Alzheimer's disease prevention and treatment strategies.
- A review of medical and surgical procedures for the risk of accidental Aβ seed transmission is warranted.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
What Happens During Stress
In response to stress, the neurons in the...
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Plant hormones—or phytohormones—are chemical molecules that modulate one or more physiological processes of a plant. In animals, hormones are often produced in specific glands and circulated via the circulatory system. However, plants lack hormone-producing glands.
Instead, plant hormones are often produced in regions of active growth, like the tips of roots and shoots. Additionally, even very low concentrations of plant hormones can have a profound effect on growth and development...
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
The Process
Starting in the stomach, when proteins are detected by sensory neurons of the enteric nervous system, the pyloric gland is stimulated to release gastrin. In turn, this hormone induces the release of histamine. Combined,...
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.