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Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
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Clinical Efficacy of a Novel Therapeutic Principle, Anakoinosis

Daniel Heudobler1, Michael Rechenmacher1, Florian Lüke1

  • 1Department of Internal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany.

Frontiers in Pharmacology
|December 15, 2018
PubMed

Insights

Anakoinosis, a novel cancer therapy, reprograms tumor communication and gene expression. This approach uses "master modulators" to achieve cancer control with favorable toxicity, offering a new principle beyond traditional treatments.

Area of Science:

  • Oncology
  • Systems Biology
  • Cancer Therapeutics

Background:

  • Classic cancer therapies face limitations due to genetic factors and undruggable targets.
  • Tumor heterogeneity and resistance mechanisms hinder treatment efficacy.
  • Existing treatments often involve high toxicity and limited long-term success.

Purpose of the Study:

  • To introduce anakoinosis, a novel therapeutic concept based on communicative reprogramming of tumor tissues.
  • To define "master modulators" as agents that promote evolutionary processes or regulate homeostatic pathways in cancer.
  • To explore anakoinosis as an alternative to conventional cytotoxic and targeted therapies.

Main Methods:

  • Summarizing data and trials on anakoinosis-inducing schedules.
  • Identifying drugs and drug combinations capable of reprogramming tumor tissues (e.g., transcriptional modulators, metronomic chemotherapy, epigenetic agents, differentiation therapies).
  • Analyzing the efficacy and toxicity profiles of anakoinosis-based treatments.

Main Results:

  • Data from 97 anakoinosis-inducing schedules show a favorable toxicity profile.
  • Combined administration of master modulators can induce complete remission in refractory metastatic cancers, irrespective of tumor type.
  • Treatment efficacy is dependent on situational system characteristics rather than solely histology.

Conclusions:

  • Anakoinosis represents a new therapeutic principle in cancer treatment.
  • This approach effectively targets recessive tumor components through regulatory drug combinations.
  • Anakoinosis offers a promising alternative with a favorable toxicity profile for managing refractory metastatic neoplasia.
Keywords:
AnakoinosisCOX-2 inhibitorall-trans retinoic acidcommunicative reprogrammingglitazonesmaster modulatorsmetronomic low-dose chemotherapytranscriptional modulators

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