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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Overview of Hematopoiesis01:20

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
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Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis...
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Bone Structure01:55

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Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
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Bone Marrow Fat and Hematopoiesis.

Huifang Wang1, Yamei Leng1, Yuping Gong1

  • 1Department of Hematology, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in Endocrinology
|December 15, 2018
PubMed
Summary
This summary is machine-generated.

Bone marrow fat (BMF) is an active organ influencing energy storage, bone metabolism, and hematopoiesis. This review explores BMF

Keywords:
aplastic anemiabone marrow fathematopoiesisleukemiamultiple myeloma

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Area of Science:

  • Endocrinology
  • Hematology
  • Metabolic Research

Background:

  • Bone marrow adipocytes (BMAs) were once considered inert fillers but are now recognized as the third largest fat depot.
  • Bone marrow fat (BMF) functions as a metabolically active organ involved in energy storage and endocrine regulation.

Purpose of the Study:

  • To review the multifaceted roles of bone marrow fat in hematopoiesis.
  • To examine the influence of BMF on the development and progression of hematologic diseases.

Main Methods:

  • Literature review of current scientific data.
  • Analysis of the interaction between bone marrow adipocytes and hematopoietic stem cells.
  • Examination of adipocyte-derived factors in the bone marrow microenvironment.

Main Results:

  • BMF significantly impacts hematopoiesis through direct cellular contact and secreted factors.
  • BMAs influence the progression of hematologic malignancies like leukemia and multiple myeloma.
  • BMF plays a role in aplastic anemia and may be a therapeutic target.

Conclusions:

  • Bone marrow fat is a critical regulator of hematopoiesis and a key player in hematologic diseases.
  • Understanding BMF's functions offers potential for novel therapeutic strategies in hematology.