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Updated: Feb 1, 2026

IgY Technology: Extraction of Chicken Antibodies from Egg Yolk by Polyethylene Glycol PEG Precipitation
Published on: May 1, 2011
A green, catalyst-free synthesis of pyrazolopyranopyrimidines in polyethylene glycol as a biodegradable medium at
Rezvan Kardooni1,2, Ali Reza Kiasat3
1Department of Chemistry, Khuzestan Science and Research Branch, Islamic Azad University, Ahvaz, Iran. rezvankardooni@ymail.com.
Abstract:
A facile, efficient and environmentally safe strategy for the synthesis of pyrazolopyranopyrimidines via one-pot, four-component reaction of hydrazine hydrate, barbituric acid, ethyl acetoacetate, and aromatic aldehydes in polyethylene glycol (PEG) as a safe solvent in the absence of catalyst at ambient temperature has been described. The advantages of the present protocol, such as simplicity, mild conditions, high yields of products, straightforward workup procedure, a green and biodegradable reaction medium, make this new process an attractive to current methodologies.
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