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[Apalcillin and renal function].

J P Fillastre1, B Moulin, S Josse

  • 1Service de Néphrologie, UER de Médecine, Rouen.

Pathologie-Biologie
|June 1, 1988
PubMed
Summary
This summary is machine-generated.

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This study investigated the renal effects of apalcilline, a new penicillin antibiotic. While apalcilline decreased para-aminohippuric acid clearance, it did not cause significant renal dysfunction in healthy volunteers.

Area of Science:

  • Pharmacology
  • Nephrology
  • Clinical Trials

Background:

  • A new semi-synthetic penicillin, apalcilline, has been used in over 4,000 patients.
  • Elevated serum creatinine was observed in 18 patients, with apalcilline suspected in 5 cases.
  • The potential renal impact of apalcilline warrants further investigation.

Purpose of the Study:

  • To evaluate the effects of apalcilline on renal function in healthy volunteers.
  • To assess the impact of apalcilline on specific renal clearance mechanisms and electrolyte excretion.

Main Methods:

  • A controlled study involving three periods: control, treatment (apalcilline infusion), and post-treatment.
  • Measurement of creatinine, inulin, and para-aminohippuric acid (PAH) clearances.
  • Analysis of urinary electrolytes, volume, and B2-microglobulin excretion.

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Main Results:

  • No significant changes were observed in creatinine or inulin clearances.
  • Urinary electrolyte output remained unchanged.
  • A significant decrease in PAH clearance was noted during apalcilline infusion, suggesting competitive inhibition of proximal tubular secretion.

Conclusions:

  • Apalcilline may compete with PAH for renal tubular secretion.
  • Despite decreased PAH clearance, apalcilline did not induce significant renal dysfunction in healthy individuals.
  • Further research may be needed to fully elucidate the renal safety profile of apalcilline.