[Pharmacokinetics and tolerance of ceftriaxone after subcutaneous administration]

Having affirmed that a dose of 2 g ceftriaxone (CTRX) administered subcutaneously (SC) to healthy volunteers was well absorbed, the same dose administered to eight patients first intravenously (days 1 to 3), then SC (days 4 to 6). Plasma levels obtained after SC administration are similar to those obtained after IV administration and are consistent with drug therapeutic efficacy. The poor tolerance of CTRX when administered SC represents a very important limiting factor on the administration of a 2 g dose via this path.