Related Experiment Video
Updated: Feb 1, 2026

Spatially Compact Arrangement of Larval Zebrafish Sections for Spatial Transcriptomic Analysis
Published on: May 16, 2025
Enantiopure C1-Cyclotriveratrylene with a Reversed Spatial Arrangement of the Substituents
Augustin Long1, Cedric Colomban1, Marion Jean1
1Aix Marseille Univ, CNRS, Centrale Marseille , iSm2 , Marseille , France.
Abstract:
Cyclotriveratrylene (CTV) is a macrocyclic cyclophane presenting a bowl-shaped conformation, used as building block to construct cryptophane and hemicryptophane capsules. A method to synthesize new enantiopure CTV derivatives with an unprecedented spatial arrangement of their substituents, exhibiting C1 symmetry, is described. The absolute configuration was assigned by ECD spectroscopy coupled with modeling. A statistical model has allowed for optimization of the proportion of C1 CTV, and the modularity of this approach is also highlighted.
Related Concept Videos
Fascicle Arrangement in Skeletal Muscles
The four primary types of muscle based on fascicle arrangement are:
Directing Effect of Substituents: meta-Directing Groups
Radical Substitution: Halogenation of Alkanes and Alkyl Substituents
In the initiation step of the reaction, the chlorine molecule undergoes homolytic cleavage in the presence of light or heat, forming two highly reactive chlorine radicals. Propagation occurs in two...
Nomenclature of Aromatic Compounds with a Single Substituent
Directing Effect of Substituents: ortho–para-Directing Groups
Nomenclature of Aromatic Compounds with Multiple Substituents
For disubstituted benzene derivatives, with two groups attached to the benzene ring, three constitutional isomers are possible. For example, consider dimethyl benzene, often called xylene, where the second methyl group can be substituted at the second, third, or fourth carbon. The relative position of the substituents is represented by prefixes ortho, meta, or...

