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Staphylococcal Plasmids, Transposable and Integrative Elements

Neville Firth1, Slade O Jensen2, Stephen M Kwong1

  • 1School of Life and Environmental Sciences, University of Sydney, New South Wales 2006, Australia.

Microbiology Spectrum
|December 15, 2018
PubMed

Insights

Mobile genetic elements like plasmids and transposons drive antimicrobial resistance in Staphylococcus aureus. Understanding these elements is key to combating dangerous staphylococcal infections.

Area of Science:

  • Microbiology
  • Genetics
  • Infectious Diseases

Background:

  • Staphylococcus aureus is a major cause of illness and death.
  • Antimicrobial resistance in staphylococci complicates treatment.
  • Mobile genetic elements are crucial for the spread of resistance.

Purpose of the Study:

  • To review mobile genetic elements in staphylococci.
  • To focus on elements spreading antimicrobial resistance genes.
  • To understand their role in gene mobility and expression.

Main Methods:

  • Literature review of identified mobile genetic elements in staphylococci.
  • Cataloguing plasmids, transposable elements (insertion sequences, transposons), and integrative elements (ICE, SCC).
  • Analysis of their roles in horizontal gene transfer and genome modulation.

Main Results:

  • Plasmids, insertion sequences, transposons, ICE, and SCC elements are prevalent in staphylococci.
  • These elements facilitate the acquisition and dissemination of antimicrobial resistance genes.
  • They also influence gene expression and genome rearrangement.

Conclusions:

  • Mobile genetic elements are central to the evolution and spread of antimicrobial resistance in staphylococci.
  • These elements contribute to staphylococcal pathogenicity and adaptability.
  • Targeting these elements may offer novel therapeutic strategies.

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