Related Experiment Video
Updated: Feb 1, 2026

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
Published on: March 26, 2018
Right Mini-Thoracotomy Subaortic Membrane Resection
Carl A Johnson1, Juan A Siordia, Davida A Robinson
1From the Division of Cardiac Surgery, University of Rochester Medical Center, Rochester, NY USA.
Objective:
Subaortic membrane is an anatomical intracardiac anomaly that may cause discrete subaortic stenosis and aortic insufficiency. Patients requiring subaortic membrane resection may benefit from a minimally invasive approach; however, subaortic membranes are typically resected through a median sternotomy. We present our initial clinical experience of adult patients who have undergone a mini-thoracotomy subaortic membrane resection.
Methods:
Eight patients who underwent an elective subaortic membrane resection performed through a mini-thoracotomy were retrospectively reviewed. A 5-cm mini-thoracotomy incision was made in the 2nd intercostal space; a videoscope was inserted through a separate incision within the same interspace. Cardiopulmonary bypass (CPB) was instituted via central arterial and peripheral venous cannulation and an aortotomy was made. The subaortic membrane was resected with shafted instruments. The left ventricular outflow tract was inspected and CPB was weaned. Thirty-day mortality, intensive care and hospital length of stay, ventilation time, operative times, postoperative morbidity, and need for additional procedures were evaluated.
Results:
The median CPB and cross-clamp times were 60 and 42 minutes, respectively. The median time to extubation was 3.6 hours. The median intensive care unit and hospital stay were 22 hours and 3 days, respectively. The postoperative left ventricular outflow tract mean gradients decreased significantly (26.5 vs. 9.4 mm Hg, P = 0.001). There were no conversions to sternotomy, perioperative strokes, or 30-day mortality.
Conclusions:
Subaortic membranes can be resected through a mini-thoracotomy approach with excellent clinical results.
Insights
Minimally invasive mini-thoracotomy effectively resects subaortic membranes, offering an alternative to sternotomy. This approach shows excellent clinical outcomes for patients with discrete subaortic stenosis.
Area of Science:
- Cardiovascular Surgery
- Minimally Invasive Cardiac Surgery
Background:
- Subaortic membrane causes discrete subaortic stenosis and aortic insufficiency.
- Median sternotomy is the traditional approach for subaortic membrane resection.
- Minimally invasive techniques may offer benefits for patients requiring this procedure.
Purpose of the Study:
- To evaluate the initial clinical experience of subaortic membrane resection using a mini-thoracotomy approach in adult patients.
- To assess the feasibility and outcomes of this minimally invasive technique.
Main Methods:
- Retrospective review of eight adult patients undergoing elective subaortic membrane resection via mini-thoracotomy.
- Procedure involved a 5-cm incision, video assistance, cardiopulmonary bypass, and resection with specialized instruments.
- Key outcomes evaluated included operative times, length of stay, ventilation time, and postoperative morbidity.
Main Results:
- Median cardiopulmonary bypass and cross-clamp times were 60 and 42 minutes, respectively.
- Median extubation time was 3.6 hours, with short intensive care unit (22 hours) and hospital stays (3 days).
- Significant reduction in left ventricular outflow tract mean gradients (26.5 to 9.4 mm Hg) and no 30-day mortality or conversions to sternotomy were observed.
Conclusions:
- Subaortic membrane resection can be safely and effectively performed through a mini-thoracotomy approach.
- This minimally invasive technique yields excellent clinical results, comparable to traditional methods.
- Mini-thoracotomy represents a viable alternative for selected patients needing subaortic membrane resection.
Related Concept Videos
Introduction to Membrane Proteins
What are Membranes?
What are Membranes?
The Resting Membrane Potential
Membrane Fluidity
Membrane Lipids
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...

