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Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
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Hepatitis E virus infection in swine workers: A meta-analysis
Xiangyuan Huang1, Yu Huang1, Abram L Wagner2
1Department of Epidemiology, Fudan University School of Public Health, Key Laboratory of Public Health Safety (Ministry of Education), Shanghai, China.
Zoonoses and Public Health
|December 15, 2018
Summary
Swine workers show a higher prevalence of past Hepatitis E virus (HEV) infection compared to the general population. This increased risk is consistent across various swine-related occupations, confirming zoonotic transmission.
Area of Science:
- Veterinary Medicine
- Infectious Diseases
- Public Health
Background:
- Hepatitis E virus (HEV) is a significant zoonotic pathogen with swine identified as the primary natural reservoir.
- Increased HEV infection rates among swine workers are a growing public health concern due to potential occupational exposure.
Purpose of the Study:
- To calculate the pooled prevalence of IgG antibodies against HEV in swine workers and the general population.
- To compare the prevalence of HEV infection between swine workers and the general population through a meta-analysis.
Main Methods:
- A meta-analysis was conducted on 32 cross-sectional studies from 16 countries (1999-2018).
- Searches were performed in PubMed, OVID, and CNKI databases.
- A random-effect model was used to pool prevalence ratios (PR), with heterogeneity assessed by I² statistic and publication bias by Egger's test.
Main Results:
- Swine workers exhibited a significantly higher prevalence of anti-HEV IgG antibodies compared to the general population (PR = 1.52, 95% CI: 1.38-1.76).
- Subgroup analyses revealed elevated HEV IgG prevalence in swine workers in Asia (PR = 1.49) and Europe (PR = 1.93).
- Increased prevalence was observed across all examined swine-related occupations, including farmers, butchers, meat processors, pork retailers, and veterinarians.
Conclusions:
- Swine workers have a demonstrably higher prevalence of past HEV infection.
- Findings confirm zoonotic transmission of HEV from swine to swine workers, highlighting occupational risks.
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