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Strategies of Combination Drug Delivery for Immune Checkpoint Blockades

Huitong Ruan1,2,3,4, Linlin Bu2,3, Quanyin Hu2,3

  • 1Department of Pharmaceutics, School of Pharmacy, Key Laboratory of Smart Drug Delivery, Fudan University, Shanghai, 201203, China.

Advanced Healthcare Materials
|December 15, 2018
PubMed

Insights

Immune checkpoint blockades (ICB) show promise but have limitations. Combining ICB with other cancer therapies targeting the immune cycle may improve response rates and manage side effects.

Area of Science:

  • Immunology
  • Oncology
  • Cancer Therapy

Background:

  • Immune checkpoint blockades (ICB) have advanced cancer treatment by blocking regulatory receptors to enhance antitumor T-cell responses.
  • Limitations of ICB include low objective response rates (ORR) and immune-related side effects.
  • Combination treatment strategies are crucial for overcoming ICB limitations.

Purpose of the Study:

  • To review recent advancements in combining ICB with therapies targeting various stages of the cancer immune cycle.
  • To discuss the challenges and opportunities associated with ICB combination approaches.

Main Methods:

  • Literature review of recent studies on ICB combination therapies.
  • Analysis of therapies targeting different phases of the cancer immune cycle: antigen release, presentation, T-cell activation, recognition, and tumor killing.

Main Results:

  • ICB combination strategies are being explored across all stages of the cancer immune cycle.
  • These combinations aim to enhance antitumor immunity and mitigate adverse effects.
  • The review highlights progress in integrating ICB with diverse therapeutic modalities.

Conclusions:

  • Combining ICB with other cancer therapies holds significant potential for improving treatment efficacy.
  • Addressing challenges in combination strategies is key to realizing their full therapeutic benefit.
  • Further research into ICB combinations offers opportunities to advance cancer immunotherapy.
Keywords:
cancer immunity circlescancer immunotherapycombination deliverydrug deliveryimmune checkpoint blockades

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