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Published on: March 8, 2024
Gram-Scale Total Synthesis of Sarpagine Alkaloids and Non-Natural Derivatives
Heiko Rebmann1, Christa K G Gerlinger1, Tanja Gaich1
1Department of Chemistry, University of Konstanz, Universitätsstrasse 10, 78464, Konstanz, Germany.
Abstract:
This work describes the total synthesis of three members of the sarpagine alkaloid family and ten non-natural congeners through an improved synthetic sequence, which was designed for gram-scale production of materials suited for structure-activity relationship (SAR) studies. Furthermore, the manuscript details how the synthetic route was used to access the biogenetically completely unrelated Stemona alkaloid parvineostemonine (34), providing a showcase for efficient synthetic design.
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