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Updated: Feb 1, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

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Dichotomy of Notch signalling in regulating tumour immune surveillance

Ritu Khosla1, Ashish Kumar Vyas1,2, Nirupma Trehanpati1

  • 1Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.

Scandinavian Journal of Immunology
|December 15, 2018
PubMed

Insights

Notch signalling impacts cancer development, acting as both a promoter and suppressor. This review explores its role in the tumor microenvironment and anti-tumor immunity, offering insights for novel cancer therapies.

Area of Science:

  • Oncology
  • Immunology
  • Cellular Biology

Background:

  • Notch signalling is a conserved pathway crucial for development and tissue homeostasis.
  • Aberrant Notch activation is linked to cancer initiation and progression, with dual roles as promoter or suppressor.
  • The interplay between Notch signalling and the tumor immune microenvironment is an active area of research.

Purpose of the Study:

  • To review the multifaceted roles of Notch signalling in cancer.
  • To elucidate the impact of Notch signalling on anti-tumor immune responses mediated by T cells.
  • To explore therapeutic strategies targeting Notch signalling for cancer treatment, including cancer stem cell control.

Main Methods:

  • Literature review of studies on Notch signalling in cancer and immunology.
  • Analysis of Notch gene expression in T cell subsets (CD4, CD8).
  • Discussion of the tumor microenvironment and immune cell interactions.

Main Results:

  • Notch signalling exhibits context-dependent roles in tumorigenesis.
  • Notch pathway modulation in T cells influences anti-tumor immunity.
  • Specific Notch molecules and immune cells play critical roles within the tumor microenvironment.

Conclusions:

  • Notch signalling is a key regulator of the tumor immune microenvironment.
  • Understanding Notch-mediated immune responses can inform cancer therapy development.
  • Targeting Notch signalling holds potential for controlling cancer stem cells and improving treatment outcomes.
Keywords:
Notch signallingtumour immune surveillancetumour-infiltrating lymphocytes cancer stem cells

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