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Multiple psychological factors predict abdominal pain severity in children with irritable bowel syndrome

John M Hollier1,2, Miranda A L van Tilburg3,4,5, Yan Liu6

  • 1Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Neurogastroenterology and Motility
|December 15, 2018
PubMed

Insights

Psychological factors like somatization and pain catastrophizing mediate anxiety and depression

Area of Science:

  • Pediatric Gastroenterology
  • Clinical Psychology
  • Medical Psychology

Background:

  • Anxiety and depression are linked to abdominal pain in pediatric irritable bowel syndrome (IBS).
  • The role of other psychological factors in this association remains unclear.

Purpose of the Study:

  • To investigate if somatization and pain catastrophizing mediate the relationship between anxiety/depression and IBS abdominal pain severity in children.
  • To identify potential therapeutic targets for pediatric IBS.

Main Methods:

  • Utilized baseline data from pediatric IBS clinical studies.
  • Conducted mediation analysis to assess the role of somatization and pain catastrophizing.
  • Analyzed data from 261 pediatric IBS participants.

Main Results:

  • All psychological factors (anxiety, depression, somatization, pain catastrophizing) were positively correlated with IBS abdominal pain severity.
  • Somatization and pain catastrophizing significantly mediated the association between anxiety and IBS pain.
  • Somatization and pain catastrophizing also mediated the association between depression and IBS pain.

Conclusions:

  • Somatization and pain catastrophizing are key mediators in the link between anxiety/depression and abdominal pain in pediatric IBS.
  • These psychological factors may represent more effective treatment targets than anxiety and depression alone.
  • Clinical assessment and intervention for somatization and pain catastrophizing are recommended for pediatric IBS patients.
Abstract

Keywords:
anxietydepressionirritable bowel syndromemediation analysispain catastrophizingpediatricpsychological factorssomatization

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