Related Experiment Video
Updated: Feb 1, 2026

Covalent Binding of BMP-2 on Surfaces Using a Self-assembled Monolayer Approach
Published on: August 26, 2013
The interaction of chitosan and BMP-2 tuned by deacetylation degree and pH value
Qun Wang1,2, Menghao Wang1, Pengfei Li3
1Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, 610031, China.
Abstract:
Integrating proteins with chitosan (CS) can not only improve the biocompatibility of CS, but also enable the sustained release of proteins. The deacetylation degree (DD) and pH conditions are considered as the two most important factors affecting the interaction between CS and proteins. In this study, the effects of CS with different DDs and pH conditions on bone morphogenetic protein-2 (BMP-2) adsorption were evaluated using the molecular dynamics (MD) method. The results showed that the interaction energy first increased and then decreased, with the increase of the DD in the range of 0-100%; the strongest interaction was found between BMP-2 and 75% DD-CS surface. Furthermore, decreasing pH values favor the interaction between BMP-2 and CS surfaces. These results are useful to gain a better understanding of the interaction mechanism between polysaccharides and proteins and provide a meaningful reference for the application of CS with different DDs and pH conditions. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 769-779, 2019.
Related Concept Videos
One-Degree-of-Freedom System
A one-degree-of-freedom system is defined by an independent variable that determines its state and behavior. One example of a one-degree-of-freedom system is a simple harmonic oscillator, such as a...
Degrees of Freedom
For example, suppose there are three unknown numbers whose mean is 10; although we can freely assign values to the first and second numbers, the value of the last number can not be arbitrarily assigned.
Degrees of Freedom
For example, suppose there are three unknown numbers whose mean is 10; although we can freely assign values to the first and second numbers, the value of the last number can not be arbitrarily...
Degree of Unsaturation
The degree of unsaturation for hydrocarbons is U = (2C + 2 − H) / 2, where C is the number of carbon atoms and H is the number of hydrogen atoms.
Radian and Degree Measure
Problem-Solving: Tuning of a Guitar String
The string's wave speed can be regulated by varying the linear density. Tension is the other property that determines the speed of...

