Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Urinary Bladder01:23

Urinary Bladder

3.4K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
3.4K
Aging01:26

Aging

701
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
701
What is Conservation Biology?01:57

What is Conservation Biology?

24.3K
Conservation biology is a scientific field that focuses on the preservation of biodiversity in order to protect ecosystems while meeting the needs of the human population. Humans require properly functioning ecosystems to maintain our supply of natural resources, including food, medicines, and building materials.
24.3K
Biological Effects of Radiation02:59

Biological Effects of Radiation

17.9K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
17.9K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.5K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.5K
Anatomy of the Genitourinary System II: Bladder and Urethra01:19

Anatomy of the Genitourinary System II: Bladder and Urethra

1.6K
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chronic Bladder Ischemia Enhances Mechanosensitive Afferent C-Fiber Activity: Insights From a Newly Developed Female Rat Model.

Lower urinary tract symptoms·2026
Same author

Efficacy of Peak Frequency in Pulmonary Vein Isolation Using Pulsed Field Ablation for Atrial Fibrillation.

Journal of cardiovascular electrophysiology·2025
Same author

Prospective Multicenter Registry to Investigate the Clinical Feasibility of Combination Workflow With 90 W/4 s and Ablation Index-Guided 50 W Ablation (PRECISE-COMBO 90 W/50 W Study).

Journal of arrhythmia·2025
Same author

Clinical and Prognostic Utility of the Essential Frailty Toolset in Older Patients With Heart Failure.

Journal of the American Geriatrics Society·2025
Same author

Intravesical substance P enhances bladder afferent nerve activity without the influence of the micturition reflex.

Naunyn-Schmiedeberg's archives of pharmacology·2025
Same author

Very high-power short-duration ablation for superior vena cava isolation in patients with recurrent atrial fibrillation.

Journal of cardiology·2025
Same journal

[Development of novel therapeutics for multiple myeloma and improvement of drug lag].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Clinical pharmacy services to patients of immunomodulatory drugs].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Therapeutic drug monitoring of the new anti-myeloma drugs in the treatment of multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Prognostic value of minimal residual disease assessment using next-generation sequencing in multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[The evaluation of minimal residual disease in multiple myeloma by an allele-specific oligonucleotide real-time PCR].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Evaluation of minimal residual disease in myeloma by multiparametric flow cytometry].

Nihon rinsho. Japanese journal of clinical medicine·2019
See all related articles

Related Experiment Video

Updated: Feb 1, 2026

Mouse Bladder Wall Injection
03:48

Mouse Bladder Wall Injection

Published on: July 12, 2011

24.8K

Ageing-related bladder functional and biological changes.

Naoki Aizawa

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |December 15, 2018
    PubMed
    Summary
    This summary is machine-generated.

    As populations age, more elderly individuals experience lower urinary tract symptoms (LUTS), including detrusor hyperactivity with impaired contractility (DHIC). This review explores individual factors like hormonal changes and oxidative stress contributing to these age-related urological conditions.

    More Related Videos

    Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
    10:13

    Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

    Published on: February 14, 2014

    14.2K
    Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
    11:46

    Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

    Published on: April 27, 2014

    18.4K

    Related Experiment Videos

    Last Updated: Feb 1, 2026

    Mouse Bladder Wall Injection
    03:48

    Mouse Bladder Wall Injection

    Published on: July 12, 2011

    24.8K
    Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
    10:13

    Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

    Published on: February 14, 2014

    14.2K
    Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
    11:46

    Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

    Published on: April 27, 2014

    18.4K

    Area of Science:

    • Urology
    • Gerontology
    • Cellular Biology

    Background:

    • Global populations are rapidly aging, leading to an increase in age-related diseases.
    • Lower urinary tract symptoms (LUTS), particularly detrusor hyperactivity with impaired contractility (DHIC), are prevalent in elderly patients.
    • Individual variability in LUTS and their underlying causes is significant.

    Purpose of the Study:

    • To review the involvement of various factors in the development of age-related LUTS, with a focus on DHIC.
    • To synthesize findings from functional and biological investigations in rodents.
    • To highlight the individual nature of aging-related bladder dysfunction.

    Main Methods:

    • Literature review of functional and biological investigations.
    • Analysis of rodent models studying bladder aging.
    • Synthesis of data on hormonal factors, intrinsic bladder changes, and oxidative stress.

    Main Results:

    • Ageing impacts bladder function through hormonal alterations, intrinsic changes like fibrosis and denervation, and increased oxidative stress.
    • These factors contribute to the development of LUTS and DHIC in elderly individuals.
    • Rodent studies provide insights into the biological mechanisms underlying age-related bladder dysfunction.

    Conclusions:

    • Age-related LUTS, including DHIC, are multifactorial, influenced by hormonal, intrinsic, and oxidative stress-related changes.
    • Understanding these individual factors is crucial for managing LUTS in an aging population.
    • Further research in this area can lead to targeted therapeutic strategies for age-related urological conditions.