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Updated: Feb 1, 2026

Mouse Bladder Wall Injection
Published on: July 12, 2011
Ageing-related bladder functional and biological changes
Abstract:
One of the major global demographic trends is the rapid ageing population, and the num- ber of people with ageing-related diseases has been increasing. In the urological field, ageing-related lower urinary tract symptoms (LUTS), especially detrusor hyperactivity with impaired contractility (DHIC), are commonly observed among elderly patients. However, such ageing-related LUTS and their backgrounds widely vary by individual. Previous reports using functional- and biological-investigations in rodents revealed the possible relationship between ageing and individual factors related to bladder function, which were hormonal fac- tors, intrinsic changes (fibrosis and denervation) and oxidative stress, etc. Here, I reviewed involvement of such factors on ageing-related LUTS including DHIC.
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