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Current multidisciplinary approaches for metastatic prostate cancer.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|December 15, 2018
Summary
Prostate cancer is rising in Asia. New treatments combining androgen deprivation therapy with docetaxel chemotherapy or radiotherapy improve survival for metastatic prostate cancer patients.
Area of Science:
- Oncology
- Urology
Background:
- Prostate cancer incidence is rapidly increasing in Asian populations, becoming the most common male cancer in Japan.
- Androgen deprivation therapy (ADT) is the standard first-line treatment for metastatic prostate cancer (mPCa), but resistance develops within 3-5 years, leading to metastatic castration-resistant prostate cancer (mCRPC).
Purpose of the Study:
- To review current multidisciplinary treatment strategies for metastatic prostate cancer (mPCa) and metastatic castration-resistant prostate cancer (mCRPC).
Main Methods:
- Review of recent multicenter, randomized trials and reported data on treatment outcomes.
- Synthesis of evidence regarding the impact of chemotherapy and radiotherapy in mPCa management.
Main Results:
- Addition of docetaxel chemotherapy to ADT has demonstrated improved overall survival in first-line mPCa treatment.
- Radiotherapy to the prostate shows a significant impact on survival, even in patients with mPCa.
Conclusions:
- Management paradigms for mPCa are evolving with new combination therapies.
- Multidisciplinary approaches integrating ADT, chemotherapy, and radiotherapy are crucial for improving outcomes in mPCa and mCRPC.
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