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Updated: Feb 1, 2026

Intravital Imaging of the Mouse Popliteal Lymph Node
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A Case of Unicentric Castleman Disease and Langerhans Cell Histiocytosis: Two Entities in One Lymph Node

Xiaoyun Liu, Lingling Liu, Ling Zhang

    Clinical Laboratory
    |December 15, 2018
    PubMed

    Insights

    Castleman disease (CD) and Langerhans cell histiocytosis (LCH) can rarely occur together. This case report highlights the importance of recognizing this rare combination for accurate diagnosis and treatment.

    Area of Science:

    • Hematology
    • Oncology
    • Pathology

    Background:

    • Castleman disease (CD) is a lymphoproliferative disorder.
    • Langerhans cell histiocytosis (LCH) is a clonal disease of the monocyte-macrophage system.

    Observation:

    • A rare case of coexistent Castleman disease and Langerhans cell histiocytosis was diagnosed in a single lymph node.
    • Hematologic investigation and intrapulmonary mass biopsy were performed.

    Findings:

    • The patient achieved complete remission.
    • No signs of recurrence have been observed to date.

    Implications:

    • Recognizing this rare morphologic combination is crucial for accurate diagnosis of coexistent CD and LCH.
    • Adequate tissue sampling is essential to avoid misdiagnosis.

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