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Thiol-Disulfide Homeostasis in Cerebral Venous Sinus Thrombosis

Gonul Vural, Sadiye Gumusyayla, Orhan Deniz

    Clinical Laboratory
    |December 15, 2018
    PubMed

    Insights

    Patients with cerebral venous sinus thrombosis exhibit impaired thiol-disulfide homeostasis, with lower thiol levels correlating to more extensive thrombosis. This suggests potential therapeutic benefits from thiol-fortifying agents.

    Area of Science:

    • Biochemistry
    • Neurology
    • Thrombosis Research

    Background:

    • Cerebral venous sinus thrombosis (CVST) is a condition affecting venous blood drainage from the brain.
    • Oxidative stress is implicated in various thrombotic disorders.
    • Thiol-disulfide homeostasis plays a crucial role in cellular redox balance.

    Purpose of the Study:

    • To investigate thiol-disulfide homeostasis in patients diagnosed with cerebral venous sinus thrombosis.
    • To determine if alterations in thiol and disulfide levels are associated with CVST.
    • To explore potential correlations between thiol-disulfide balance and thrombosis severity.

    Main Methods:

    • A cohort of 53 CVST patients and 80 healthy controls was analyzed.
    • Automated measurement of native thiol and total thiol concentrations.
    • Calculation of disulfide bond amounts and correlation analysis with clinical parameters.

    Main Results:

    • CVST patients showed significantly lower total thiol and native thiol levels compared to healthy controls.
    • No significant difference in dynamic disulfide bond formation was observed between groups.
    • A negative correlation was found between thiol levels and the extent of sinus thrombosis.

    Conclusions:

    • This is the first study to report on thiol-disulfide homeostasis in CVST.
    • The findings indicate a disruption in thiol-disulfide balance in CVST patients, linked to thrombosis severity.
    • Supplementation with agents like N-acetyl cysteine or alpha-lipoic acid may be beneficial for CVST treatment.
    Abstract

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