Related Experiment Video
Updated: Feb 1, 2026

Manual Restraint and Common Compound Administration Routes in Mice and Rats
Published on: September 26, 2012
[Analysis of the treatment effects of refractory sudden total frequency deafness with steroid from different topical
1Department of Otorhinolaryngology, the Third People's Hospital of Wuxi, Wuxi, 214041, China.
Abstract:
Objective:To compare the efficacy between intratympanic dexamethasone and postauricular injection of methylprednisolone treatment for refractory sudden total frequency deafness. Method:Forty-eight cases of refractory sudden total frequency deafness were randomly divided into A group and B group (n=24 in each group). A group received intratympanic injection of dexamethasone 0.5 ml, and B group received postauricular injection of methylprednisolone 40 mg. Both treatments were performed once every other day for 2 weeks. The hearing was reviewed 2 weeks after the treatment. Result:In A group, 1 case was cured, 2 cases were markedly effective, 6 cases were effective, 15 cases were ineffective, the total effective rate was 37.5%; in B group, 0 cases were cured, 1 case was markedly effective, 4 cases were effective, 19 cases were ineffective, the total effective rate was 20.8%. There was no significant difference between the two groups in the total effective rate (P>0.05). The average PTA of patient in the A group and B group were respectively increased by (15.13±11.77) dB and (8.71±9.72) dB, and the difference was statistically significant (t=2.059, P<0.05). Conclusion:Both topical injection treatments of glucocorticoids can be recommended for patients with refractory sudden total frequency deafness, while intratympanic dexamethasone may be more advantageous in improving hearing threshold.
Related Concept Videos
Routes of Drug Administration: Parenteral
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
Routes of Drug Administration: Overview
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
Additional Routes of Drug Administration
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Routes of Drug Administration: Enteral
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
Routes of Persuasion
Dosage Interval and Administration Route: Determination Methods

