[Analysis of distant metastasis and related factors of head and neck mucosal melanoma]

Objective:To analyze the characteristics and related factors of distant metastasis of head and neck mucosal melanoma, so as to provide better help for the treatment and the control of patients' survival. Method:Retrospectively analyze the patients of head and neck mucosal melanoma who were treated in our hospital from January 2004 to December 2016, through follow-up, of which 37 cases of patients with metastatic disease were analyzed which including the incidence of distant metastasis, specific metastasis and prognosis, time, etc.The age and gender of the patients were controlled, and 37 cases of 1∶1 were selected randomly in the patients who had no distant metastasis. χ² test, Kaplan-Meier analysis and multiple factor logistics regression model were used to analyze the related factors of distant metastasis of head and neck mucosal melanoma. Result: The time from hospitalization to distant metastasis was 5-98 months, and the median progression time was 18 months. 27 people died in the 37 cases, 10 people were still alive,which lung metastasis accounted for 32.43%(12/37) , peritoneal metastasis accounted for 16.22% (6/37), bone metastases accounted for 5.41%(2/37), the presence of multiple organ metastasis (lung, liver, brain) patients accounted for 45.95%(17/37).χ² test and Kaplan_Meier analysis showed that no matter whether there was pigmentation or not, postoperative radiotherapy, AJCC staging and operation mode were the significant factors.Finally,multiple factor logistics regression model showed AJCC staging, and the presence of pigment deposition was associated with metastasis. Conclusion: There is a wide variety of multiple organ metastasis when found.Less brain metastases. According to the AJCC stage, patients with advanced stage usually predict poor prognosis and distant metastasis after operation.The patients' lesion without pigmented melanoma have a great chance of distant metastasis..