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Related Concept Videos

Appendicitis-I: Introduction01:22

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The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
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Laparoscopic versus open appendectomy for complicated appendicitis.

Cristóbal Del Pino1, Rodrigo Muñoz2, Gabriel Rada3

  • 1Proyecto Epistemonikos, Santiago, Chile.

Medwave
|December 15, 2018
PubMed
Summary
This summary is machine-generated.

Laparoscopic appendectomy likely reduces hospital stay and wound infection risk for acute appendicitis. However, evidence on intra-abdominal abscess risk remains unclear due to low certainty.

Keywords:
EpistemonikosGRADEappendicitisopen appendectomyLaparoscopic appendectomy

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Area of Science:

  • Surgical Innovation
  • Gastrointestinal Surgery
  • Evidence-Based Medicine

Background:

  • Laparoscopic appendectomy offers benefits like reduced wound infection and faster recovery for acute appendicitis.
  • A key concern with laparoscopy is an increased risk of intra-abdominal abscess, a complication of complicated appendicitis.

Purpose of the Study:

  • To systematically review and meta-analyze evidence comparing laparoscopic versus open appendectomy for acute appendicitis.
  • To evaluate the impact of laparoscopic appendectomy on outcomes such as wound infection, hospitalization time, and intra-abdominal abscess formation.

Main Methods:

  • Conducted a comprehensive search of systematic reviews in Epistemonikos, including MEDLINE, EMBASE, and Cochrane databases.
  • Extracted data from systematic reviews, reanalyzed primary study data, performed a meta-analysis, and utilized the GRADE approach for certainty of evidence.

Main Results:

  • Included six systematic reviews encompassing 55 studies, with four randomized trials.
  • Laparoscopic appendectomy probably reduces hospital stay duration compared to open surgery.
  • The risk of wound infection may be reduced with laparoscopy, but evidence is limited.

Conclusions:

  • Laparoscopic appendectomy appears to shorten hospital stays and potentially decrease wound infection rates.
  • The certainty of evidence regarding intra-abdominal abscess incidence following laparoscopic appendectomy is very low, requiring further investigation.