Integration of clinical information and molecular biology profile -Endeavor of SCRUM-Japan-

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Extraction of Histones from Clinical Specimens for Epigenetic Profiling by Mass Spectrometry
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Extraction of Histones from Clinical Specimens for Epigenetic Profiling by Mass Spectrometry

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Wataru Okamoto, Takayuki Yoshino

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |December 15, 2018
    PubMed

    Insights

    Biomarker-driven therapies are advancing colorectal cancer treatment. To overcome challenges in developing drugs for small patient groups, the nationwide SCRUM-Japan genome screening project was initiated.

    Area of Science:

    • Oncology
    • Genomics
    • Precision Medicine

    Background:

    • Biomarker-based therapies are increasingly used in colorectal cancer (CRC).
    • Development of targeted therapies for genetic alterations like BRAF mutations and microsatellite instability (MSI) is ongoing for CRC patients.
    • Fragmented patient populations based on biomarkers pose challenges for developing novel treatments.

    Purpose of the Study:

    • To accelerate the development of therapeutic agents for rare or small patient populations in CRC.
    • To address the challenges posed by biomarker-driven patient stratification in drug development.

    Main Methods:

    • Implementation of a nationwide genome screening project named 'SCRUM-Japan'.
    • Focus on identifying patients with specific gene alterations relevant to CRC treatment.

    Main Results:

    • The SCRUM-Japan project aims to facilitate the development of targeted therapies.
    • Facilitates enrollment of patients into clinical trials based on identified genomic profiles.

    Conclusions:

    • Nationwide genome screening projects like SCRUM-Japan are crucial for advancing precision medicine in oncology.
    • Accelerating the development of novel treatments for biomarker-defined patient subgroups in colorectal cancer is achievable through collaborative screening efforts.

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